Sulfasalazine Side Effects (Cont.)

Serious Sulfasalazine Side Effects

Some side effects with sulfasalazine, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
 
  • Anemia
 
 
  • Hallucinations
 
  • Yellowing of the eyes or skin (jaundice)
 
  • Easy bruising or unusual paleness
 
  • Decreased urination or painful urination
 
  • Signs of an allergic reaction, including:
 
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 

Rare Sulfasalazine Side Effects

There are other, less common sulfasalazine side effects that can occur less frequently. Because these side effects are so rare, it is difficult to tell whether they are actually caused by sulfasalazine or something else.
 
These rare sulfasalazine side effects include but are not limited to:
 
  • Vertigo (a spinning sensation)
  • Insomnia
  • Tinnitus (ringing in the ears)
  • Drowsiness
  • Skin discoloration
  • Urine discoloration.
     

Sulfasalazine Side Effects: Final Thoughts

You may experience some or none of the sulfasalazine side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug, or if something "just does not seem right." While it may not be a side effect of sulfasalazine, your healthcare provider will be able to diagnose and treat the problem.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;