Sulfasalazine Drug Class

Healthcare providers often recommend the drug sulfasalazine (Azulfidine®) to their patients with ulcerative colitis. This inflammatory bowel disease (IBD) is characterized by rectal bleeding and diarrhea, among other symptoms. This medication is also available in a delayed-release form to treat rheumatoid arthritis.
This drug is classified as an aminosalicylate, which means that sulfasalazine works by inhibiting the production of inflammatory chemicals in the lining of the colon. Specifically, it decreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation caused by ulcerative colitis.
(Click What Is Sulfasalazine Used For? to learn more about how this drug works, whether children can take it, and possible off-label uses.)
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