Sulfasalazine and Psoriatic Arthritis

Though not approved for psoriatic arthritis, sulfasalazine is occasionally used to treat this condition. Sulfasalazine went generic a long time ago, which means it is unlikely to be approved for anything other than its officially licensed uses. In addition, methotrexate (a somewhat similar medication), is generally preferred over this drug for the treatment of psoriatic arthritis.

Treating Psoriatic Arthritis With Sulfasalazine

Sulfasalazine (Azulfidine®, Azulfidine EN-tabs®) is a medication sometimes used to treat psoriatic arthritis, although it is not approved for this use. Azulfidine and Azulfidine EN-tabs are similar medications, except that the EN-tabs come in an extended-release tablet form instead of an immediate-release tablet.

Using Sulfasalazine Off-Label

Sulfasalazine is officially approved for the following conditions:
Notice that while sulfasalazine is approved for treating rheumatoid arthritis and juvenile rheumatoid arthritis, it is not approved for treating psoriatic arthritis. This does not mean, however, that your healthcare provider cannot prescribe the drug for this use. It is probably just a reflection of the fact that sulfasalazine is a fairly old medication that has long since "gone generic" and is, therefore, unlikely to be approved for any new uses.
It is very expensive to fund studies and apply for new approvals, and generic manufacturers are unlikely to do so, and neither are brand-name manufacturers, once a drug is available as a generic. Despite the "off-label" (unapproved) status of sulfasalazine for psoriatic arthritis treatment, it can be an appropriate medication in some individuals.
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