How Does Sulfasalazine Work?

Sulfasalazine (Azulfidine®) is a medication used to treat ulcerative colitis in adults and children over the age of six. It belongs to a class of drugs known as aminosalicylates and is sold in tablet form.
 
How does sulfasalazine work? To answer that question, it's important to know that the inflammation caused by ulcerative colitis is thought to be caused by two kinds of chemicals: prostaglandins and leukotrienes. Sulfasalazine works within the colon to inhibit the production of these two chemicals; this action helps reduce inflammation.
 
(Click Sulfasalazine to learn more about how this drug works. This full-length article also describes how to take it, what to expect during treatment, what to discuss with your healthcare provider beforehand, and more.)
 
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