Drug Interactions With Sulfasalazine

If certain medications are combined, potentially negative drug interactions may occur. Medicines that may cause drug interactions with sulfasalazine include warfarin, folic acid, and digoxin. These interactions may lead to a decreased effectiveness of the medicines. If drug interactions with sulfasalazine are a concern, your healthcare provider may need to adjust your dosages.

 

Drug Interactions With Sulfasalazine: An Introduction

Sulfasalazine (Azulfidine®) can potentially interact with a few other medicines. Some of the medicines that may lead to drug interactions with sulfasalazine include:
 
  • Digoxin (Digitek®, Lanoxin®)
  • Folic acid
  • Warfarin (Coumadin®, Jantoven®).
     

Sulfasalazine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when sulfasalazine is combined with any of the drugs listed above.
 
Digoxin
Sulfasalazine may decrease the absorption of digoxin into your body, perhaps making it less effective. Your healthcare provider should monitor the level of digoxin in your blood, especially when you are starting or stopping sulfasalazine.
 
Folic Acid
Sulfasalazine may decrease the absorption of folic acid into your body. Ask your healthcare provider about taking folic acid supplements, especially if you are a woman of childbearing age.
 
Warfarin
Sulfasalazine may interact with warfarin. Your healthcare provider should monitor you more closely and adjust your warfarin dosage as necessary to prevent drug interactions from occurring.
 
(Drug Interactions With Sulfasalazine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;