Sulfasalazine Delayed-Release

Sulfasalazine delayed-release is often prescribed to treat ulcerative colitis, rheumatoid arthritis, or juvenile rheumatoid arthritis. It works by decreasing the production of certain chemicals that can lead to inflammation. The medication comes in tablet form, and is generally taken two to six times a day. Potential side effects of sulfasalazine delayed-release include loss of appetite, vomiting, and headaches.

 

What Is Sulfasalazine Delayed-Release?

Sulfasalazine delayed-release (Azulfidine EN-tabs®) is a prescription medication that is used to treat the following conditions:
 
(Click What Is Sulfasalazine Delayed-Release Used For? for more information, including possible off-label uses.)
 

Who Makes Sulfasalazine Delayed-Release?

Sulfasalazine delayed-release is manufactured by Pfizer, Inc.
 

How Does Sulfasalazine Delayed-Release Work?

Sulfasalazine delayed-release belongs to a group of medications called aminosalicylates. It is thought that the medication works by inhibiting the production of inflammatory chemicals in the lining of the colon. It decreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation of ulcerative colitis.
 
It is not fully understood how exactly sulfasalazine delayed-release works for rheumatoid arthritis and juvenile rheumatoid arthritis. However, it is thought that the medication likely works by decreasing inflammation and affecting the immune system.
 
Sulfasalazine delayed-release has a special "enteric coating," which prevents the tablets from dissolving until they reach the stomach. This helps prevent stomach irritation.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;