Sulfasalazine Delayed-Release

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking sulfasalazine delayed-release if you have:
  • Difficulty passing urine
  • An intestinal blockage
  • Porphyria (problems with certain enzymes in the body)
  • Kidney disease, including kidney failure (renal failure)
  • Liver disease, including liver failure or cirrhosis
  • Anemia or any other low blood cell count
  • Asthma
  • Any allergies, including allergies to sulfa drugs, food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Sulfasalazine Delayed-Release to learn more, including information on who should not take the drug.) 

How Does Sulfasalazine Delayed-Release Work?

Sulfasalazine delayed-release belongs to a group of medications called aminosalicylates. It is thought that the medication works by inhibiting the production of inflammatory chemicals in the lining of the colon. It decreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation of ulcerative colitis.
It is not fully understood how exactly sulfasalazine delayed-release works for rheumatoid arthritis and juvenile rheumatoid arthritis. However, it is thought that the medication likely works by decreasing inflammation and affecting the immune system.
Sulfasalazine delayed-release has a special "enteric coating," which prevents the tablets from dissolving until they reach the stomach. This helps prevent stomach irritation.
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Sulfasalazine Delayed-Release Drug Information

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