Drug Interactions With Sulfasalazine Delayed-Release

Potentially negative drug interactions can occur when certain medications are taken together. Medicines that can cause drug interactions with sulfasalazine delayed-release include warfarin, folic acid, and digoxin. These interactions may lead to a decreased effectiveness of the medicines. If drug interactions with sulfasalazine delayed-release are a concern, your healthcare provider may adjust your doses as necessary.

 

Drug Interactions With Sulfasalazine Delayed-Release: An Introduction

Sulfasalazine delayed-release (Azulfidine EN-tabs®) can potentially interact with a few other medicines. Some of the medicines that may lead to drug interactions with sulfasalazine delayed-release include:
 
  • Digoxin (Digitek®, Lanoxin®)
  • Folic acid
  • Warfarin (Coumadin®, Jantoven®).
     

Sulfasalazine Delayed Release Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when sulfasalazine delayed-release is combined with any of the drugs listed above.
 
Digoxin
Sulfasalazine delayed-release may decrease the absorption of digoxin into your body, perhaps making it less effective. Your healthcare provider should monitor the level of digoxin in your blood, especially when you are starting or stopping sulfasalazine delayed-release.
 
Folic Acid
Sulfasalazine delayed-release may decrease the absorption of folic acid into your body. Ask your healthcare provider about taking folic acid supplements, especially if you are a woman of childbearing age.
 
Warfarin
Sulfasalazine delayed-release may interact with warfarin. Your healthcare provider should monitor you more closely and adjust your warfarin dosage as necessary to prevent this interaction from occurring.
 
(Drug Interactions With Sulfasalazine Delayed-Release Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;