Natalizumab Side Effects

Common Side Effects

Natalizumab has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving natalizumab were carefully documented, along with the side effects that occurred in a similar group of people receiving a placebo injection (an injection with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common side effects of natalizumab included:
  • Headaches -- in up to 38 percent of people
  • Fatigue -- up to 27 percent
  • Respiratory tract infections (such as the common cold) -- up to 22 percent
  • Urinary tract infection (UTI) -- up to 21 percent
  • Joint pain -- up to 19 percent
  • Depression -- up to 19 percent
  • Nausea -- up to 17 percent
  • Pain in the arms and legs -- up to 16 percent
  • Rash -- up to 12 percent
  • Flu-like symptoms -- up to 12 percent
  • Back pain -- up to 12 percent.
Other common side effects, occurring in 1 to 11 percent of people, included:
  • Stomach flu
  • Abdominal (stomach) discomfort and pain
  • Vaginal discharge, itching, and pain
  • Diarrhea
  • Tooth infections and toothaches
  • Urgency to urinate, increased frequency of urination, or loss of bladder control
  • Herpes infections
  • Sinus congestion
  • Inflammation of the tonsils (tonsillitis)
  • Red, itchy skin
  • Coughing
  • Infections from viruses (viral infections)
  • Swelling of the arms, hands, legs, ankles, or feet
  • A whirling sensation and loss of balance
  • Sinus and throat pain
  • Chest discomfort
  • Heartburn or indigestion
  • Muscle cramps
  • Abnormal liver function tests
  • Irregular or absence of menstruation (periods)
  • Painful menstruation (painful periods)
  • Allergic reactions, including reactions to the intravenous (IV) infusion
  • Constipation
  • Seasonal allergies
  • Injury to the arms or legs
  • Chills
  • Gas
  • Weight changes
  • Skin cuts
  • Joint swelling
  • Cysts on the ovaries
  • Sleepiness
  • Canker sores
  • Burns
  • Tremors
  • Dry skin.
Know the Signs - Concussion Safety

Natalizumab Drug Information

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