The recommended dose of natalizumab is the same for everyone -- 300 mg administered through an intravenous (IV) infusion every four weeks. This infusion typically takes about one hour. You will be carefully monitored for at least one hour after each dose is given, as this drug can cause potentially serious reactions like vomiting, breathing problems, and dizziness.
An Introduction to Dosing With NatalizumabThere is only one standard dose of natalizumab (Tysabri®), regardless of your age or weight. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Natalizumab Dosage for Multiple SclerosisThe standard dosage of natalizumab for treating multiple sclerosis is 300 mg once every four weeks. The dose is given slowly into a vein (called an IV infusion) at a rate of about 5 mg per minute. At this rate, it takes approximately one hour to administer the entire dosage.
Natalizumab Dosage for Crohn's DiseaseThe standard dosage of natalizumab for treating Crohn's disease is 300 mg once every four weeks. The dose is given slowly into a vein at a rate of about 5 mg per minute. At this rate, it takes approximately one hour to administer the entire dosage.
Treatment should be stopped if a benefit is not seen within 12 weeks. Treatment should also be stopped if corticosteroids (such as prednisone) cannot be discontinued within six months of starting natalizumab, or if corticosteroids are needed to help control Crohn's disease symptoms for more than three months in a one-year period.
Regardless of whether you receive natalizumab for multiple sclerosis or Crohn's disease, you will be carefully monitored while receiving your dosage and for at least one hour after it is given. This is because some people may experience a potentially serious reaction to the natalizumab infusion. Let your healthcare provider know if you experience any symptoms of such a reaction, which may include:
- Nausea and vomiting
- Sudden redness and warmth of the face, neck, and chest (flushing)
- Shortness of breath or wheezing
- Low blood pressure (hypotension), which could cause dizziness or fainting.