Mesalamine Drug Interactions

Mesalamine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when mesalamine is combined with any of the drugs listed above.
 
Antacids
One specific brand of mesalamine (Apriso™) should not be taken with antacids, as this may cause the mesalamine to be released in the stomach, instead of the colon (where it is intended to work).
 
Azathioprine
Mesalamine may decrease the body's ability to metabolize azathioprine, perhaps increasing the risks of side effects of azathioprine. Check with your healthcare provider before taking these medications together.
 
Digoxin (Digitek, Lanoxin)
Mesalamine may decrease the absorption of digoxin into your body, perhaps making it less effective. Your healthcare provider should monitor the level of digoxin in your blood, especially when you are starting or stopping mesalamine.
 
H2 Blockers
One specific brand of mesalamine (Apriso) should not be taken with H2 blockers, as this may cause the mesalamine to be released in the stomach, instead of the colon (where it is intended to work).
  
Mercaptopurine
Mesalamine may decrease the body's ability to metabolize mercaptopurine, perhaps increasing the risks of side effects of mercaptopurine. Check with your healthcare provider before taking these medications together.
 
Proton Pump Inhibitors (PPIs)
One specific brand of mesalamine (Apriso) should not be taken with PPIs, as this may cause the mesalamine to be released in the stomach, instead of the colon (where it is intended to work).
  
Thioguanine
Mesalamine may decrease the body's ability to metabolize thioguanine perhaps increasing the risks of side effects of thioguanine. Check with your healthcare provider before taking these medications together.

Mesalamine Drug Information

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