If you have ulcerative colitis, your healthcare provider may prescribe Uceris. This medication is available as a tablet that is taken once a day in the morning for up to eight weeks. This is the standard dose that is given to everyone, regardless of age or weight. Side effects are possible and can include nausea, headaches, and respiratory infections.
Uceris is a corticosteroid. It works by decreasing inflammation, which is one of the problems in ulcerative colitis. Steroids are often needed to help people control flares (temporary worsenings) of ulcerative colitis. However, unlike most other steroids, Uceris is less likely to cause the typical steroid side effects, which can be quite bothersome or serious.
Uceris tablets are uniquely designed with both an enteric coating and extended-release properties. The enteric coating is designed to dissolve only in the intestine (not in the stomach), after which the tablet will slowly release the medication throughout the colon.
As an added advantage, when Uceris is absorbed into the body, the liver changes most of it into other compounds that do not have steroid side effects. The medication works mostly when it comes into contact with the colon; therefore, it does not need to circulate throughout the body to work.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Uceris [package insert]. San Diego, CA: Santarus, Inc.;2013 January.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed March 6, 2013.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed March 6, 2013.
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