Pentasa is medicine licensed for the treatment of ulcerative colitis. It can significantly improve symptoms and help prevent flare-ups from returning. The prescription drug is available in the form of controlled-release capsules, which are specially designed to dissolve slowly over time to allow the medication to be released throughout the intestinal tract. Side effects of Pentasa may include diarrhea and nausea.
Pentasa belongs to a group of medications called aminosalicylates. It is thought that the drug works by inhibiting the production of inflammatory chemicals in the lining of the colon. Pentasa decreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation caused by ulcerative colitis.
The capsules are controlled-release, meaning they dissolve slowly over time. This allows the medication to be released throughout the gastrointestinal tract.
Effects of Pentasa
In clinical studies, people taking Pentasa experienced fewer symptoms of ulcerative colitis (including fever, trips to the toilet, bleeding, and pain) when compared to those not taking the medication.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed April 18, 2007.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed April 18, 2007.
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