Colitis Home > Natalizumab Side Effects

While most people can receive natalizumab without experiencing problems, side effects are possible with this prescription medicine. Some of the most common reactions include headaches, a rash, and joint pain. Most of these problems are easy to treat. However, you may need medical treatment if you experience natalizumab side effects such as vision problems, weakness on one side of the body, or difficulty breathing.

An Introduction to Side Effects of Natalizumab

Just like any medicine, natalizumab (Tysabri®) can cause side effects. However, not everyone who receives the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with natalizumab. Your healthcare provider can discuss a more complete list with you.)

Serious Natalizumab Side Effects

Some side effects of natalizumab are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing
  • Intense abdominal (stomach) pain, swelling, or cramps
  • Inability to have a bowel movement
  • Signs of infection, such as:
  • Reactions during or shortly after receiving a natalizumab infusion, such as:
    • Hives
    • Itching
    • Rash
    • Headaches
    • Dizziness
    • Fatigue
    • Chills
    • Fever
    • Nausea and vomiting
    • Sudden redness and warmth of the face, neck, and chest (flushing)
    • Shortness of breath or wheezing
    • Low blood pressure (hypotension)
  • Weakness on one side of the body
  • Vision problems
  • Confusion
  • Problems with thinking and memory
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Tiredness or fatigue
    • Pain in the upper-right area of the abdomen (stomach)
    • Nausea and vomiting.
Some natalizumab side effects have been reported months after treatment ended. Therefore, be sure to tell your healthcare provider about any potentially serious side effect you develop, both during treatment and for several months after you stop using natalizumab.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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