Colitis Home > Natalizumab

Drug Interactions

Natalizumab may react with a few other medicines (see Drug Interactions With Natalizumab).

What If I Overdose on This Medicine?

It is not entirely clear what to expect from an overdose with natalizumab. Seek immediate medical attention if you or someone else may have overdosed on this medication.
(Click Tysabri Overdose for more information.)

What If I Miss a Dose of Natalizumab?

If you miss an appointment to receive a dose of natalizumab, contact your healthcare provider right away to reschedule. It is important to try to keep all of your healthcare appointments while receiving this medication.

How Does It Work?

An antibody (also known as an immunoglobulin) is a protein made by the immune system. Antibodies bind to substances in the body called antigens. Natalizumab is an anti-alpha-4-integrin antibody. This means it binds to and blocks alpha-4-integrin.
Apha-4-integrins are molecules found on most white blood cells (immune cells). They help white blood cells bind to other cells. When white blood cells bind to certain other cells in blood vessels near the brain, the white blood cells can get into the brain, where they can damage myelin. When white blood cells bind to certain cells in the gastrointestinal tract, they may cause inflammation.
The exact way natalizumab works for MS and Crohn's disease is not entirely known. It is believed that by blocking alpha-4-integrin, natalizumab prevents white blood cells from binding to other cells. This prevents white blood cells from getting into the brain and attacking nerves, which can help with MS, and from causing inflammation in the gastrointestinal tract, which can help with Crohn's disease.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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