Colitis Home > Delzicol

Delzicol is a drug licensed for the treatment of ulcerative colitis. This prescription medicine comes as a capsule that is taken three times a day. It works by decreasing inflammation in the lining of the colon. Although most people tolerate this medicine well, side effects are possible and include a sore throat, belching, and abdominal (stomach) pain.


What Is Delzicol?

Delzicol® (mesalamine) is a prescription medication used to treat ulcerative colitis. It comes in the form of a capsule. This product is a replacement for Asacol® 400 mg tablets, which are no longer available.
(Click Delzicol Uses for more information, including possible off-label uses.)

Who Makes It?

Delzicol is manufactured by Warner Chilcott (US), LLC.

How Does Delzicol Work?

Delzicol belongs to a group of medications called aminosalicylates. It is believed to work by inhibiting the production of inflammatory chemicals in the lining of the colon. As a result, the medication decreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation of ulcerative colitis.
The capsules contain the medication in a special resin that does not dissolve in the highly acidic stomach, but instead in the much less acidic intestines.  

Clinical Effects

Delzicol was approved based on studies involving the tablet formulation, which was sold under the name Asacol. In these studies, people taking Asacol experienced less bleeding and diarrhea than those not taking the medication. The medication was also shown to help prevent ulcerative colitis symptoms from returning.
One interesting study looked at the effect of Asacol on male infertility. Sulfasalazine (a similar medication for ulcerative colitis) often causes male infertility. In this small study, men who developed infertility while taking sulfasalazine were switched to Asacol. All men showed improved sperm count, and eight out of nine men showed improved sperm motility.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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