Colitis Home > Collagenous Colitis

Making a Diagnosis

A collagenous colitis diagnosis is made after tissue samples taken during colonoscopy (or flexible sigmoidoscopy) are examined under a microscope. Collagenous colitis is characterized by a larger-than-normal band of protein called collagen inside the lining of the colon. The thickness of the band varies, so multiple tissue samples from different areas of the colon may need to be examined.
People with collagenous colitis are most often diagnosed in their 50s, although some cases have been reported in adults younger than 45 years and in children between the ages of 5 and 12. It is diagnosed more frequently in women than in men.

Treatment for Collagenous Colitis

Collagenous colitis treatment varies depending on the symptoms and severity of the disease. It has been known to go away on its own, but most people with this condition have recurrent symptoms.
Lifestyle changes aimed at improving diarrhea are usually tried first. Recommended changes include:
  • Reducing the amount of fat in the diet
  • Eliminating foods that contain caffeine or lactose
  • Not using NSAIDs.
If lifestyle changes alone are not enough, medications are often used to control the symptoms of collagenous colitis.
Antidiarrheal medications (such as bismuth subsalicylate) and bulking agents (such as fiber supplements) can help reduce diarrhea. Anti-inflammatory medications, such as mesalamine, sulfasalazine, and steroids (including budesonide), reduce inflammation. Immunosuppressive agents, which reduce the autoimmune response, are rarely needed.
For very extreme cases of collagenous colitis, bypass of the colon or surgery to remove all or part of the colon have been done on occasion. However, these surgeries are rarely recommended.
Written by/reviewed by:
Last reviewed by: Arthur Schoenstadt, MD
Last updated/reviewed:
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