Colitis Home > Azulfidine

Azulfidine has been approved for the treatment of ulcerative colitis. It works by decreasing the production of certain chemicals in the lining of the colon that lead to inflammation. The medication, which is available by prescription and comes in tablet form, is generally taken three to six times a day. Possible side effects of Azulfidine include nausea or vomiting, headache, and loss of appetite.

What Is Azulfidine?

Azulfidine® (sulfasalazine) is a prescription medication that is used to treat ulcerative colitis. It is also available in a delayed-release tablet form (see Azulfidine EN-Tabs), which is approved for the treatment of rheumatoid arthritis.
(Click Azulfidine Uses for more information, including possible off-label uses.)

Who Makes Azulfidine?

It is manufactured by Pfizer, Inc.

How Does It Work?

Azulfidine belongs to a group of medications called aminosalicylates. It is thought that Azulfidine works by inhibiting the production of inflammatory chemicals in the lining of the colon. The medication decreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation caused by ulcerative colitis.

When and How to Take Azulfidine

General considerations include the following:
  • The medication comes in tablet form. It is generally taken by mouth, usually three to six times per day.
  • Azulfidine can be taken with or without food. If the drug bothers your stomach, try taking it with food.
  • It should be taken at the same times each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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