Colitis Home > Azulfidine Side Effects

While most people have no problems when taking Azulfidine, it is possible for side effects to occur. Common ones include nausea or vomiting, headache, loss of appetite, and reversible low sperm count in men. While these side effects are typically mild, some side effects of Azulfidine are serious and should be reported to a healthcare provider immediately, including anemia, jaundice, and decreased or painful urination.

Azulfidine Side Effects: An Introduction

As with any medicine, side effects are possible with Azulfidine® (sulfasalazine); however, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Azulfidine. Your healthcare provider can discuss a more complete list of Azulfidine side effects with you. For side effects of Azulfidine EN-tabs delayed-release tablets, see Azulfidine EN-tabs Side Effects.)
 

Common Side Effects of Azulfidine

Azulfidine has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
In these studies, the most common Azulfidine side effects included:
 
  • Loss of appetite
  • Headache
  • Nausea or vomiting
  • Reversible low sperm count in men.
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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