Colitis Home > Azulfidine Drug Interactions

When Azulfidine is taken with medications like warfarin, folic acid, or digoxin, drug interactions may occur. These interactions can decrease the absorption of the medicines in your blood, which may reduce the drugs' effectiveness. If drug interactions with Azulfidine are a concern, your healthcare provider may adjust your dosages or monitor you more closely.

Azulfidine Interactions: An Overview

Azulfidine® (sulfasalazine) can potentially interact with a few other medicines. Some of the medicines that may lead to Azulfidine drug interactions include:

Azulfidine Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Azulfidine is combined with any of the drugs listed above.
Azulfidine may decrease the absorption of digoxin into your body, perhaps making it less effective. Your healthcare provider should monitor the level of digoxin in your blood, especially when you are starting or stopping Azulfidine.
Folic Acid
Azulfidine may decrease the absorption of folic acid into your body. Ask your healthcare provider about taking folic acid supplements, especially if you are a woman of childbearing age.
Azulfidine may interact with warfarin, perhaps affecting how the medication is absorbed or decreasing its effectiveness. Your healthcare provider should monitor you more closely and adjust your warfarin dosage as necessary.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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