What Is Infliximab Used For?

How Infliximab Works

Infliximab is part of a class of medicines known as tumor necrosis factor inhibitors, or TNF inhibitors for short. As the name implies, infliximab blocks the activity of tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a naturally occurring chemical in the body that is involved in inflammation and other immune system functions.
People with rheumatoid arthritis, psoriasis, ankylosing spondylitis, ulcerative colitis, or Crohn's disease often have higher levels of TNF. These high levels can cause inflammation and lead to problems. By blocking TNF-alpha, infliximab helps to relieve the symptoms of these conditions and, in some cases, prevent future damage from occurring.

Is Infliximab Used for Children?

Infliximab has been studied in children as young as six years old for Crohn's disease and ulcerative colitis. However, it is not approved for any other use in children. Talk with your healthcare provider about the benefits and risks of using infliximab in children.

Are There Off-Label Infliximab Uses?

On occasion, your healthcare provider may recommend infliximab for something other than the conditions discussed in this article. This is called an "off-label" use. At this time, off-label uses for infliximab include treatment of the following conditions:
  • Behcet's disease (a condition involving chronic inflammation throughout the body)
  • Acute graft-versus-host disease (which may occur after a bone marrow transplant).
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Infliximab Drug Information

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