Side Effects of Azathioprine

Side effects of azathioprine are typically minor and either require no treatment or are easily treated by you and your healthcare provider. Common azathioprine side effects include leukopenia, infections, and nausea or vomiting. Uncommon side effects of azathioprine include hair loss, joint pain, and diarrhea. You should, however, notify your healthcare provider if you experience more serious side effects, such as unusual bleeding or bruising or any signs of liver problems or infections.

 

Side Effects of Azathioprine: An Introduction

As with any medicine, side effects are possible with azathioprine (Imuran®). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with azathioprine. Your healthcare provider can discuss a more complete list of azathioprine side effects with you.)
 

Common Side Effects of Azathioprine

Azathioprine has been studied thoroughly in clinical trials, in which the side effects of a group of people taking the drug are documented and compared to another group not taking the medicine. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
In these studies, the most common azathioprine side effects included:
 
  • Leukopenia (low levels of a certain type of white blood cells called leukocytes) -- in up to 50 percent of people
  • Infections -- up to 20 percent
  • Nausea and vomiting -- up to 12 percent.
     
(Side Effects of Azathioprine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;