Drug Interactions With Azathioprine

More Information on Interactions With Azathioprine

The following sections explain in detail the potentially negative interactions that can occur when azathioprine is combined with any of the drugs listed above.
Allopurinol inhibits one of the enzymes that helps to remove azathioprine from the body. If you take these medications together, your healthcare provider should reduce your azathioprine dosage to about one-third to one-fourth of the usual dose.
Aminosalicylates can increase the level of azathioprine in your blood, potentially increasing the risk of side effects of azathioprine. Your healthcare provider may need to decrease your azathioprine dosage to prevent this interaction from occurring.
Angiotensin-Converting Enzyme Inhibitors
Combining an ACE inhibitor with azathioprine can increase your risk of anemia or leukopenia (low levels of certain white blood cells called leukocytes). Talk to your healthcare provider before taking these medications together.
There have been reports of a very aggressive and fatal form of cancer known as hepatosplenic T-cell lymphoma in people who took infliximab with azathioprine, especially in young males being treated for Crohn's disease or ulcerative colitis. You and your healthcare provider should carefully discuss this risk before combining these two medications.
Sulfamethoxazole and Trimethoprim
Taking azathioprine with sulfamethoxazole and trimethoprim can increase your risk of leukopenia. Talk to your healthcare provider before taking these medications together.
Azathioprine may decrease the effectiveness of warfarin, possibly increasing your risk of blood clots. Your healthcare provider should monitor you closely and adjust your warfarin dosage as necessary.
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