Asacol HD Warnings and Precautions

Before you start treatment, warnings and precautions for Asacol HD should be discussed with your healthcare provider. For example, this medicine may cause kidney damage and worsen the symptoms of ulcerative colitis. Asacol HD may be less effective in people with pyloric stenosis, so be sure to tell your healthcare provider if you have this condition before starting treatment.

Asacol HD: What Should I Tell My Healthcare Provider?

You should talk to your healthcare provider prior to taking Asacol HD® (mesalamine) if you have:
  • Pyloric stenosis (narrowing of the outlet of the stomach)
  • Kidney disease, including kidney failure (renal failure)
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • Any other allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Asacol HD Precautions and Warnings

Precautions and warnings to be aware of prior to taking Asacol HD include the following:
  • Asacol HD may be less effective in people with pyloric stenosis. Pyloric stenosis may delay the release of Asacol HD into the colon (where it is effective).
  • This medication may cause a worsening of ulcerative colitis. Be sure to tell your healthcare provider if your ulcerative colitis symptoms worsen when you start taking Asacol HD.
  • Asacol HD may cause kidney damage. Your healthcare provider should check your kidney function (using a blood test) before you start the drug and periodically thereafter.
  • There have been a few cases of liver failure possibly related to the use of mesalamine (the active ingredient in Asacol HD), particularly in people who already have liver disease.
  • Some people notice intact Asacol HD tablets in their stool. This is not normal and should be reported to your healthcare provider.
  • Asacol HD can interact with certain medications (see Asacol HD Drug Interactions).
  • Asacol HD is considered a pregnancy Category B medicine. This means that it is relatively safe for use during pregnancy, although the full risks are currently unknown. If you are pregnant, discuss these risks with your healthcare provider before using Asacol HD (see Mesalamine and Pregnancy for more information).
  • If you are breastfeeding, it is known that Asacol HD passes through breast milk. Therefore, if you are breastfeeding, be sure to check with your healthcare provider before taking Asacol HD (see Mesalamine and Breastfeeding).

Asacol HD Drug Information

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