Apriso is a prescription medicine approved for the treatment of ulcerative colitis. It works by decreasing the production of prostaglandins and leukotrienes, chemicals in the lining of the colon that lead to the inflammation of ulcerative colitis. The drug comes in the form of an extended-release capsule and is typically taken once a day. Potential side effects include diarrhea, headache, and nausea.

What Is Apriso?

Apriso™ (mesalamine) is a prescription medication used to treat ulcerative colitis. It is a long-acting version of mesalamine that is taken just once a day.
(Click Apriso Uses for more information, including possible off-label uses.)

Who Makes It?

Apriso is manufactured by Catalent Pharma Solutions for Salix Pharmaceuticals, Inc.

How Does Apriso Work?

Apriso belongs to a group of medications called aminosalicylates. It is thought that Apriso works by inhibiting the production of inflammatory chemicals in the lining of the colon. It decreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation of ulcerative colitis.
Apriso capsules are extended-release, which allows them to be taken just once daily. They are also delayed-release, designed to delay the release of the medication until it passes through the stomach (allowing the medication to be released in the small and large intestines).

When and How to Take Apriso

Some general considerations include the following:
  • The medication comes in capsule form. It is usually taken by mouth once daily in the morning.
  • You can take Apriso with or without food. If it bothers your stomach, try taking it with food.
  • Do not take this medication with antacids, as this will interfere with the release mechanism of the capsules (making them less effective).
  • The capsules should not be opened, chewed, or crushed. Be sure to swallow them whole.
  • For this medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.

Apriso Drug Information

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